Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathway

OBJECTIVE: Hyperglycemia is associated with albuminuria and renal glomerular endothelial dysfunction in patients with diabetic nephropathy. The mTOR and RhoA/ROCK signaling pathways are involved in glomerular filtration barrier (GFB) regulation, but their role in high glucose (HG)-induced GFB dysfun...

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Detalles Bibliográficos
Autores principales: Chen, Xiaolin, Chen, Jianhui, Li, Xianfan, Yu, Zengpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501565/
https://www.ncbi.nlm.nih.gov/pubmed/34627341
http://dx.doi.org/10.1186/s13098-021-00723-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501565/
https://www.ncbi.nlm.nih.gov/pubmed/34627341
http://dx.doi.org/10.1186/s13098-021-00723-7

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