Cargando…

Activation of mTOR mediates hyperglycemia-induced renal glomerular endothelial hyperpermeability via the RhoA/ROCK/pMLC signaling pathway

OBJECTIVE: Hyperglycemia is associated with albuminuria and renal glomerular endothelial dysfunction in patients with diabetic nephropathy. The mTOR and RhoA/ROCK signaling pathways are involved in glomerular filtration barrier (GFB) regulation, but their role in high glucose (HG)-induced GFB dysfun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Xiaolin, Chen, Jianhui, Li, Xianfan, Yu, Zengpu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501565/ https://www.ncbi.nlm.nih.gov/pubmed/34627341 http://dx.doi.org/10.1186/s13098-021-00723-7

Ejemplares similares

High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway
por: Zhao, Hongran, et al.
Publicado: (2022)

Simvastatin Alleviates Hyperpermeability of Glomerular Endothelial Cells in Early-Stage Diabetic Nephropathy by Inhibition of RhoA/ROCK1
por: Peng, Hui, et al.
Publicado: (2013)

QiShenYiQi Pills Attenuates Ischemia/Reperfusion-Induced Cardiac Microvascular Hyperpermeability Implicating Src/Caveolin-1 and RhoA/ROCK/MLC Signaling
por: Pan, Chun-Shui, et al.
Publicado: (2021)

Porcine Sapovirus-Induced Tight Junction Dissociation via Activation of the RhoA/ROCK/MLC Signaling Pathway
por: Sharif, Muhammad, et al.
Publicado: (2021)

MiR-31 Regulates Rho-Associated Kinase-Myosin Light Chain (ROCK-MLC) Pathway and Inhibits Gastric Cancer Invasion: Roles of RhoA
por: Chen, Zhuo, et al.
Publicado: (2016)

O-GlcNAcylation promotes migration and invasion in human ovarian cancer cells via the RhoA/ROCK/MLC pathway
por: Niu, Yichao, et al.
Publicado: (2017)

Herb-Partitioned Moxibustion Improves Crohn's Disease-Associated Intestinal Fibrosis by Suppressing the RhoA/ROCK1/MLC Pathway
por: Zhao, Min, et al.
Publicado: (2021)

Rotavirus-Induced Early Activation of the RhoA/ROCK/MLC Signaling Pathway Mediates the Disruption of Tight Junctions in Polarized MDCK Cells
por: Soliman, Mahmoud, et al.
Publicado: (2018)

The RhoA/ROCK Pathway Ameliorates Adhesion and Inflammatory Infiltration Induced by AGEs in Glomerular Endothelial Cells
por: Rao, Jialing, et al.
Publicado: (2017)

Doxorubicin Promotes Migration and Invasion of Breast Cancer Cells through the Upregulation of the RhoA/MLC Pathway
por: Liu, Chien-Liang, et al.
Publicado: (2019)

Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling
por: Kosla, Jan, et al.
Publicado: (2013)

A TRANSCRIPTIONAL CROSS–TALK BETWEEN RhoA AND c–Myc INHIBITS THE RhoA/Rock–DEPENDENT CYTOSKELETON
por: Sauzeau, Vincent, et al.
Publicado: (2010)

Involvement of Histamine and RhoA/ROCK in Penicillin Immediate Hypersensitivity Reactions
por: Han, Jiayin, et al.
Publicado: (2016)

The RhoA-ROCK pathway in the regulation of T and B cell responses
por: Ricker, Edd, et al.
Publicado: (2016)

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
por: Wang, Jirong, et al.
Publicado: (2023)

RhoA, ROCK-1, and ROCK-2 Gene Expression and Polymorphisms in Cholesteatoma Patients
por: Görür, Kemal, et al.
Publicado: (2021)

Inflammatory Immune Cytokine TNF-α Modulates Ezrin Protein Activation via FAK/RhoA Signaling Pathway in PMVECs Hyperpermeability
por: Zhou, Qun, et al.
Publicado: (2021)

Mechanism of RhoA regulating benign prostatic hyperplasia: RhoA-ROCK-β-catenin signaling axis and static & dynamic dual roles
por: Shan, Shidong, et al.
Publicado: (2023)

Axon growth inhibition by RhoA/ROCK in the central nervous system
por: Fujita, Yuki, et al.
Publicado: (2014)

Protective Effects of the mTOR Inhibitor Everolimus on Cytoskeletal Injury in Human Podocytes Are Mediated by RhoA Signaling
por: Jeruschke, Stefanie, et al.
Publicado: (2013)

Correction: RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
por: Wang, Jirong, et al.
Publicado: (2023)

RhoA and RhoC Are Both Required for the ROCK II-Dependent Promotion of Centrosome Duplication
por: Kanai, Masayuki, et al.
Publicado: (2010)

ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements
por: Seccia, Teresa M., et al.
Publicado: (2020)

Relationship between PI3K/mTOR/RhoA pathway-regulated cytoskeletal rearrangements and phagocytic capacity of macrophages
por: Bao, H.R., et al.
Publicado: (2020)

Pennogenin Tetraglycoside Induces Rat Myometrial Contraction and MLC20 Phosphorylation via PLC-IP(3) and RhoA/Rho Kinase Signaling Pathways
por: Wang, Limei, et al.
Publicado: (2012)

The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
por: Glotfelty, Elliot J., et al.
Publicado: (2023)

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock
por: Mikelis, Constantinos M., et al.
Publicado: (2015)

RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity
por: Kim, Hee-Jun, et al.
Publicado: (2020)

RhoA-ROCK Signaling as a Therapeutic Target in Traumatic Brain Injury
por: Mulherkar, Shalaka, et al.
Publicado: (2020)

EETs reduces LPS-induced hyperpermeability by targeting GRP78 mediated Src activation and subsequent Rho/ROCK signaling pathway
por: Dong, Ruolan, et al.
Publicado: (2017)

The Involvement of the RhoA/ROCK Signaling Pathway in Hypersensitivity Reactions Induced by Paclitaxel Injection
por: Pan, Chen, et al.
Publicado: (2019)

Deleted in Liver Cancer 1 (DLC1) Negatively Regulates Rho/ROCK/MLC Pathway in Hepatocellular Carcinoma
por: Wong, Carmen Chak-Lui, et al.
Publicado: (2008)

ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens
por: Priya, Rashmi, et al.
Publicado: (2017)

Coxiella burnetii Phagocytosis Is Regulated by GTPases of the Rho Family and the RhoA Effectors mDia1 and ROCK
por: Salinas, Romina P., et al.
Publicado: (2015)

RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response
por: Wang, Jiping, et al.
Publicado: (2012)

Activation of RhoA-ROCK-BMP signaling reprograms adult human corneal endothelial cells
por: Zhu, Ying-Ting, et al.
Publicado: (2014)

Azilsartan protects against hyperglycemia-induced hyperpermeability of the blood-brain barrier
por: Han, Jing, et al.
Publicado: (2021)

Effects of Dexmedetomidine on the RhoA /ROCK/ Nox4 Signaling Pathway in Renal Fibrosis of Diabetic Rats
por: Jihua, Chen, et al.
Publicado: (2019)

Enhanced Cellular Cryopreservation by Biopolymer-Associated Suppression of RhoA/ROCK Signaling Pathway
por: Lee, Tae Wook, et al.
Publicado: (2021)

RhoA/ROCK Signaling Pathway Mediates Shuanghuanglian Injection-Induced Pseudo-allergic Reactions
por: Han, Jiayin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_auh6kvp22h52mc05o80n86nd8c