Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line

BACKGROUND: The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic blood cells, chondrocytes, and fibroblasts were observed. However, the actual FX-...

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Detalles Bibliográficos
Autores principales: Weiner, F., Schille, J. T., Koczan, D., Wu, X.-F., Beller, M., Junghanss, C., Hewicker-Trautwein, M., Murua Escobar, H., Nolte, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501574/
https://www.ncbi.nlm.nih.gov/pubmed/34625047
http://dx.doi.org/10.1186/s12885-021-08836-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501574/
https://www.ncbi.nlm.nih.gov/pubmed/34625047
http://dx.doi.org/10.1186/s12885-021-08836-y

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