Cargando…

Novel chemotherapeutic agent FX-9 activates NF-κB signaling and induces G1 phase arrest by activating CDKN1A in a human prostate cancer cell line

BACKGROUND: The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic blood cells, chondrocytes, and fibroblasts were observed. However, the actual FX-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weiner, F., Schille, J. T., Koczan, D., Wu, X.-F., Beller, M., Junghanss, C., Hewicker-Trautwein, M., Murua Escobar, H., Nolte, I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501574/ https://www.ncbi.nlm.nih.gov/pubmed/34625047 http://dx.doi.org/10.1186/s12885-021-08836-y

Ejemplares similares

Evaluation of combination protocols of the chemotherapeutic agent FX-9 with azacitidine, dichloroacetic acid, doxorubicin or carboplatin on prostate carcinoma cell lines
por: Weiner, Franziska, et al.
Publicado: (2021)

Isoquinolinamine FX-9 Exhibits Anti-Mitotic Activity in Human and Canine Prostate Carcinoma Cell Lines
por: Schille, Jan Torben, et al.
Publicado: (2019)

Characterization of six canine prostate adenocarcinoma and three transitional cell carcinoma cell lines derived from primary tumor tissues as well as metastasis
por: Packeiser, Eva-Maria, et al.
Publicado: (2020)

TiHo-0906: a new feline mammary cancer cell line with molecular, morphological, and immunocytological characteristics of epithelial to mesenchymal transition
por: Granados-Soler, José Luis, et al.
Publicado: (2018)

An RNA-Seq-Based Framework for Characterizing Canine Prostate Cancer and Prioritizing Clinically Relevant Biomarker Candidate Genes
por: Thiemeyer, Heike, et al.
Publicado: (2021)

Suitability of ultrasound-guided fine-needle aspiration biopsy for transcriptome sequencing of the canine prostate
por: Thiemeyer, H., et al.
Publicado: (2019)

Generation and Characterisation of a Canine EGFP-HMGA2 Prostate Cancer In Vitro Model
por: Willenbrock, Saskia, et al.
Publicado: (2014)

PDA Indolylmaleimides Induce Anti-Tumor Effects in Prostate Carcinoma Cell Lines Through Mitotic Death
por: Schille, Jan Torben, et al.
Publicado: (2021)

Multiplex Gene Expression Profiling of 16 Target Genes in Neoplastic and Non-Neoplastic Canine Mammary Tissues Using Branched-DNA Assay
por: Lüder Ripoli, Florenza, et al.
Publicado: (2016)

Hormone Receptor Expression Analyses in Neoplastic and Non-Neoplastic Canine Mammary Tissue by a Bead Based Multiplex Branched DNA Assay: A Gene Expression Study in Fresh Frozen and Formalin-Fixed, Paraffin-Embedded Samples
por: Mohr, Annika, et al.
Publicado: (2016)

A Comparison of Fresh Frozen vs. Formalin-Fixed, Paraffin-Embedded Specimens of Canine Mammary Tumors via Branched-DNA Assay
por: Lüder Ripoli, Florenza, et al.
Publicado: (2016)

Molecular Characterization of the Response to Conventional Chemotherapeutics in Pro-B-ALL Cell Lines in Terms of Tumor Relapse
por: Gladbach, Yvonne Saara, et al.
Publicado: (2022)

HMGA1 and HMGA2 expression and comparative analyses of HMGA2, Lin28 and let-7 miRNAs in oral squamous cell carcinoma
por: Sterenczak, Katharina Anna, et al.
Publicado: (2014)

RNA-seq of nine canine prostate cancer cell lines reveals diverse therapeutic target signatures
por: Packeiser, Eva-Maria, et al.
Publicado: (2022)

FX11 limits Mycobacterium tuberculosis growth and potentiates bactericidal activity of isoniazid through host-directed activity
por: Krishnamoorthy, Gopinath, et al.
Publicado: (2020)

Novel Isoquinolinamine and Isoindoloquinazolinone Compounds Exhibit Antiproliferative Activity in Acute Lymphoblastic Leukemia Cells
por: Roolf, Catrin, et al.
Publicado: (2019)

Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival
por: Granados-Soler, José Luis, et al.
Publicado: (2020)

Publisher Correction: Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival
por: Granados-Soler, José Luis, et al.
Publicado: (2020)

JavaFX for dummies
por: Lowe, Doug
Publicado: (2015)

Beginning JavaFX
por: Mohan, Praveen, et al.
Publicado: (2010)

JavaFX in action
por: Morris, Simon
Publicado: (2010)

Essential JavaFX
por: Anderson, Gail, et al.
Publicado: (2009)

Quick start guide to JavaFX
por: DiMarzio, J F
Publicado: (2014)

JavaFX: a beginner's guide
por: DiMarzio, J F
Publicado: (2011)

Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways
por: Granados-Soler, José Luis, et al.
Publicado: (2022)

Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line
por: Klose, Katharina, et al.
Publicado: (2021)

JavaFX 9 by example
por: Dea, Carl, et al.
Publicado: (2017)

FX derivatives trader school
por: Jewitt, Giles
Publicado: (2015)

JavaFX developer's guide
por: Topley, Kim
Publicado: (2010)

FX options and smile risk
por: Castagna, Antonio
Publicado: (2010)

Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention
por: Alnajjar, Suhayla, et al.
Publicado: (2021)

Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines
por: Hammer, Susanne C., et al.
Publicado: (2016)

Prevalence of the Prefoldin Subunit 5 Gene Deletion in Canine Mammary Tumors
por: Hennecke, Silvia, et al.
Publicado: (2015)

Immunohistochemical investigation of Foxp3 expression in the intestine in healthy and diseased dogs
por: Junginger, Johannes, et al.
Publicado: (2012)

Mastering JavaFX 8 Controls
por: Ebbers, Hendrik
Publicado: (2014)

JavaFX 8: introduction by example
por: Dea, Carl
Publicado: (2014)

FPGA programming using FX3
por: Calleja, Stefano
Publicado: (2014)

Introducing JavaFX 8 programming
por: Schildt, Herbert
Publicado: (2015)

Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process
por: Bai, Cuicui, et al.
Publicado: (2022)

Whole genome sequencing identifies missense mutation in MTBP in Shar-Pei affected with Autoinflammatory Disease (SPAID)
por: Metzger, Julia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jtj29rn7tkof99utv226e8k8m2