Cargando…

TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

The pathogenetic mechanisms underlying neuronal death and dysfunction in Alzheimer’s disease (AD) remain unclear. However, chronic neuroinflammation has been implicated in stimulating or exacerbating neuronal damage. The tumor necrosis factor (TNF) superfamily of cytokines are involved in many syste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jayaraman, Anusha, Htike, Thein Than, James, Rachel, Picon, Carmen, Reynolds, Richard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501605/ https://www.ncbi.nlm.nih.gov/pubmed/34625123 http://dx.doi.org/10.1186/s40478-021-01264-w

Ejemplares similares

Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter
por: Picon, Carmen, et al.
Publicado: (2021)

Necroptosis Mediates TNF-Induced Toxicity of Hippocampal Neurons
por: Liu, Shan, et al.
Publicado: (2014)

Necroptosis and Neuroinflammation in Retinal Degeneration
por: Tao, Yan, et al.
Publicado: (2022)

MLKL Mediated Necroptosis Accelerates JEV-Induced Neuroinflammation in Mice
por: Bian, Peiyu, et al.
Publicado: (2017)

Necroptosis: A Novel Pathway in Neuroinflammation
por: Yu, Ziyu, et al.
Publicado: (2021)

Hyperphosphorylated tau mediates neuronal death by inducing necroptosis and inflammation in Alzheimer’s disease
por: Dong, Yue, et al.
Publicado: (2022)

Neuroprotective effect of ketamine against TNF‐α‐induced necroptosis in hippocampal neurons
por: Wang, Lu, et al.
Publicado: (2021)

TNF-α-dependent neuronal necroptosis regulated in Alzheimer's disease by coordination of RIPK1-p62 complex with autophagic UVRAG
por: Xu, Chong, et al.
Publicado: (2021)

Necroptosis and Caspase-2-Mediated Apoptosis of Astrocytes and Neurons, but Not Microglia, of Rat Hippocampus and Parenchyma Caused by Angiostrongylus cantonensis Infection
por: Zhou, Hongli, et al.
Publicado: (2020)

Oxidation of caspase-8 by hypothiocyanous acid enables TNF-mediated necroptosis
por: Bozonet, Stephanie M., et al.
Publicado: (2023)

BAD-mediated neuronal apoptosis and neuroinflammation contribute to Alzheimer's disease pathology
por: Zhang, Liansheng, et al.
Publicado: (2021)

Triclosan-induced neuroinflammation develops caspase-independent and TNF-α signaling pathway associated necroptosis in Neuro-2a cells
por: Katiyar, Parul, et al.
Publicado: (2022)

Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer's disease mouse models
por: Sai, Kazuhito, et al.
Publicado: (2023)

Necroptosis increases with age in the brain and contributes to age-related neuroinflammation
por: Thadathil, Nidheesh, et al.
Publicado: (2021)

RIP3-mediated microglial necroptosis promotes neuroinflammation and neurodegeneration in the early stages of diabetic retinopathy
por: Huang, Zijing, et al.
Publicado: (2023)

TRAIL Mediates Neuronal Death in AUD: A Link between Neuroinflammation and Neurodegeneration
por: Qin, Liya, et al.
Publicado: (2021)

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease
por: Koper, Marta J., et al.
Publicado: (2022)

Neuroinflammation and Neuronal Loss in the Hippocampus Are Associated with Immediate Posttraumatic Seizures and Corticosterone Elevation in Rats
por: Komoltsev, Ilia G., et al.
Publicado: (2021)

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
por: Balusu, Sriram, et al.
Publicado: (2023)

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease
por: Ocañas, Sarah R., et al.
Publicado: (2023)

Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation
por: Oliveira, Sara R., et al.
Publicado: (2018)

Diet-induced obesity and low testosterone increase neuroinflammation and impair neural function
por: Jayaraman, Anusha, et al.
Publicado: (2014)

DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesis
por: Altuna, Miren, et al.
Publicado: (2019)

The Neuron-Astrocyte-Microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus
por: Cerbai, Francesca, et al.
Publicado: (2012)

Exposure of neonatal rats to alcohol has differential effects on neuroinflammation and neuronal survival in the cerebellum and hippocampus
por: Topper, Lauren A., et al.
Publicado: (2015)

Post-translational modifications as key regulators of TNF-induced necroptosis
por: Liu, X, et al.
Publicado: (2016)

Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease
por: Yang, Seung-Hoon
Publicado: (2019)

Glial Cell-Mediated Neuroinflammation in Alzheimer’s Disease
por: Al-Ghraiybah, Nour F., et al.
Publicado: (2022)

Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer’s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms
por: Trovato Salinaro, Angela, et al.
Publicado: (2018)

Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation
por: Huang, Zijing, et al.
Publicado: (2018)

The effect of hyperthyroidism on cognitive function, neuroinflammation, and necroptosis in APP/PS1 mice
por: Lou, Kai, et al.
Publicado: (2023)

TNF-α Triggers RIP1/FADD/Caspase-8-Mediated Apoptosis of Astrocytes and RIP3/MLKL-Mediated Necroptosis of Neurons Induced by Angiostrongylus cantonensis Infection
por: Zhou, Hongli, et al.
Publicado: (2021)

TNFα-Mediated Necroptosis Aggravates Ischemia-Reperfusion Injury in the Fatty Liver by Regulating the Inflammatory Response
por: Yang, Faji, et al.
Publicado: (2019)

TNF-mediated alveolar macrophage necroptosis drives disease pathogenesis during respiratory syncytial virus infection
por: Santos, Leonardo Duarte, et al.
Publicado: (2021)

The link between neuroinflammation and the neurovascular unit in synucleinopathies
por: Wang, Qing, et al.
Publicado: (2023)

Exosomes as mediators of neuron-glia communication in neuroinflammation
por: Pascual, María, et al.
Publicado: (2019)

Hsp90 modulates the stability of MLKL and is required for TNF-induced necroptosis
por: Zhao, X M, et al.
Publicado: (2016)

TNF-α-mediated inflammation in cerebral aneurysms: A potential link to growth and rupture
por: Jayaraman, Thottala, et al.
Publicado: (2008)

Acute neuroinflammation provokes intracellular acidification in mouse hippocampus
por: Tyrtyshnaia, Anna A., et al.
Publicado: (2016)

Brain Trauma, Glucocorticoids and Neuroinflammation: Dangerous Liaisons for the Hippocampus
por: Komoltsev, Ilia G., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fu2thukddgqvbm3btd7komlu7b