Activation of PLCβ1 enhances endocannabinoid mobilization to restore hippocampal spike-timing-dependent potentiation and contextual fear memory impaired by Alzheimer’s amyloidosis

BACKGROUND: Accumulation of amyloid beta oligomers (AβO) in Alzheimer’s disease (AD) impairs hippocampal long-term potentiation (LTP), leading to memory deficits. Thus, identifying the molecular targets of AβO involved in LTP inhibition is critical for developing therapeutics for AD. Endocannabinoid...

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Detalles Bibliográficos
Autores principales: Lee, Jaedong, Kwag, Jeehyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501622/
https://www.ncbi.nlm.nih.gov/pubmed/34625112
http://dx.doi.org/10.1186/s13195-021-00901-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501622/
https://www.ncbi.nlm.nih.gov/pubmed/34625112
http://dx.doi.org/10.1186/s13195-021-00901-9

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