Combined nanopore adaptive sequencing and enzyme-based host depletion efficiently enriched microbial sequences and identified missing respiratory pathogens

BACKGROUND: Enzyme-based host depletion significantly improves the sensitivity of clinical metagenomics. Recent studies found that real-time adaptive sequencing of DNA molecules was achieved using a nanopore sequencing machine, which enabled effective enrichment of microbial sequences. However, few...

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Detalles Bibliográficos
Autores principales: Gan, Mingyu, Wu, Bingbing, Yan, Gangfeng, Li, Gang, Sun, Li, Lu, Guoping, Zhou, Wenhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501638/
https://www.ncbi.nlm.nih.gov/pubmed/34627155
http://dx.doi.org/10.1186/s12864-021-08023-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501638/
https://www.ncbi.nlm.nih.gov/pubmed/34627155
http://dx.doi.org/10.1186/s12864-021-08023-0

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