IP(3)R-driven increases in mitochondrial Ca(2+) promote neuronal death in NPC disease

Ca(2+) is the most ubiquitous second messenger in neurons whose spatial and temporal elevations are tightly controlled to initiate and orchestrate diverse intracellular signaling cascades. Numerous neuropathologies result from mutations or alterations in Ca(2+) handling proteins; thus, elucidating m...

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Detalles Bibliográficos
Autores principales: Tiscione, Scott A., Casas, Maria, Horvath, Jonathan D., Lam, Vincent, Hino, Keiko, Ory, Daniel S., Santana, L. Fernando, Simó, Sergi, Dixon, Rose E., Dickson, Eamonn J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501836/
https://www.ncbi.nlm.nih.gov/pubmed/34580197
http://dx.doi.org/10.1073/pnas.2110629118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501836/
https://www.ncbi.nlm.nih.gov/pubmed/34580197
http://dx.doi.org/10.1073/pnas.2110629118

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