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IP(3)R-driven increases in mitochondrial Ca(2+) promote neuronal death in NPC disease
Ca(2+) is the most ubiquitous second messenger in neurons whose spatial and temporal elevations are tightly controlled to initiate and orchestrate diverse intracellular signaling cascades. Numerous neuropathologies result from mutations or alterations in Ca(2+) handling proteins; thus, elucidating m...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501836/ https://www.ncbi.nlm.nih.gov/pubmed/34580197 http://dx.doi.org/10.1073/pnas.2110629118 |