Optimized nickase- and nuclease-based prime editing in human and mouse cells

Precise genomic modification using prime editing (PE) holds enormous potential for research and clinical applications. In this study, we generated all-in-one prime editing (PEA1) constructs that carry all the components required for PE, along with a selection marker. We tested these constructs (with...

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Detalles Bibliográficos
Autores principales: Adikusuma, Fatwa, Lushington, Caleb, Arudkumar, Jayshen, Godahewa, Gelshan I, Chey, Yu C J, Gierus, Luke, Piltz, Sandra, Geiger, Ashleigh, Jain, Yatish, Reti, Daniel, Wilson, Laurence O W, Bauer, Denis C, Thomas, Paul Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501948/
https://www.ncbi.nlm.nih.gov/pubmed/34534334
http://dx.doi.org/10.1093/nar/gkab792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501948/
https://www.ncbi.nlm.nih.gov/pubmed/34534334
http://dx.doi.org/10.1093/nar/gkab792

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