Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells

DNA is intrinsically dynamic and folds transiently into alternative higher-order structures such as G-quadruplexes (G4s) and three-way DNA junctions (TWJs). G4s and TWJs can be stabilised by small molecules (ligands) that have high chemotherapeutic potential, either as standalone DNA damaging agents...

Descripción completa

Detalles Bibliográficos
Autores principales: Zell, Joanna, Duskova, Katerina, Chouh, Leïla, Bossaert, Madeleine, Chéron, Nicolas, Granzhan, Anton, Britton, Sébastien, Monchaud, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501980/
https://www.ncbi.nlm.nih.gov/pubmed/34551430
http://dx.doi.org/10.1093/nar/gkab796

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501980/
https://www.ncbi.nlm.nih.gov/pubmed/34551430
http://dx.doi.org/10.1093/nar/gkab796

Ejemplares similares