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Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells

DNA is intrinsically dynamic and folds transiently into alternative higher-order structures such as G-quadruplexes (G4s) and three-way DNA junctions (TWJs). G4s and TWJs can be stabilised by small molecules (ligands) that have high chemotherapeutic potential, either as standalone DNA damaging agents...

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Detalles Bibliográficos
Autores principales:	Zell, Joanna, Duskova, Katerina, Chouh, Leïla, Bossaert, Madeleine, Chéron, Nicolas, Granzhan, Anton, Britton, Sébastien, Monchaud, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501980/ https://www.ncbi.nlm.nih.gov/pubmed/34551430 http://dx.doi.org/10.1093/nar/gkab796

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