Cargando…

Structure of an inactive RNA polymerase II dimer

Eukaryotic gene transcription is carried out by three RNA polymerases: Pol I, Pol II and Pol III. Although it has long been known that Pol I can form homodimers, it is unclear whether and how the two other RNA polymerases dimerize. Here we present the cryo-electron microscopy (cryo-EM) structure of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aibara, Shintaro, Dienemann, Christian, Cramer, Patrick
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501987/ https://www.ncbi.nlm.nih.gov/pubmed/34530439 http://dx.doi.org/10.1093/nar/gkab783

Ejemplares similares

Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2
por: Fianu, Isaac, et al.
Publicado: (2021)

Yeast PIC-Mediator structure with RNA polymerase II C-terminal domain
por: Schilbach, Sandra, et al.
Publicado: (2023)

Structural basis for the dimerization of Nab2 generated by RNA binding provides insight into its contribution to both poly(A) tail length determination and transcript compaction in Saccharomyces cerevisiae
por: Aibara, Shintaro, et al.
Publicado: (2017)

Structure of the Sac3 RNA-binding M-region in the Saccharomyces cerevisiae TREX-2 complex
por: Gordon, James M. B., et al.
Publicado: (2017)

Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype
por: Lapkouski, Mikalai, et al.
Publicado: (2015)

Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface
por: Aibara, Shintaro, et al.
Publicado: (2015)

The structure of a dimeric form of SARS-CoV-2 polymerase
por: Jochheim, Florian A., et al.
Publicado: (2021)

Structure of the bacteriophage PhiKZ non-virion RNA polymerase
por: de Martín Garrido, Natàlia, et al.
Publicado: (2021)

Structural and functional analyses of the interaction of archaeal RNA polymerase with DNA
por: Wojtas, Magdalena N., et al.
Publicado: (2012)

Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state
por: Osterman, Ilya A., et al.
Publicado: (2017)

Structural explanation for the role of Mn(2+) in the activity of ϕ6 RNA-dependent RNA polymerase
por: Poranen, Minna M., et al.
Publicado: (2008)

Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction
por: Westblade, Lars F., et al.
Publicado: (2010)

Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1
por: Cui, Ruixue, et al.
Publicado: (2022)

Structural basis of mitochondrial translation
por: Aibara, Shintaro, et al.
Publicado: (2020)

Structural basis for activation of Swi2/Snf2 ATPase RapA by RNA polymerase
por: Shi, Wei, et al.
Publicado: (2021)

Structural characterization of a dimer of RNA duplexes composed of 8-bromoguanosine modified CGG trinucleotide repeats: a novel architecture of RNA quadruplexes
por: Gudanis, Dorota, et al.
Publicado: (2016)

Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase
por: Shin, Yeonoh, et al.
Publicado: (2020)

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II
por: Rengachari, Srinivasan, et al.
Publicado: (2022)

RNA Polymerase II cluster dynamics predict mRNA output in living cells
por: Cho, Won-Ki, et al.
Publicado: (2016)

Solution-state structure of a fully alternately 2′-F/2′-OMe modified 42-nt dimeric siRNA construct
por: Podbevsek, Peter, et al.
Publicado: (2010)

Crystal structure of dimeric human PNPase reveals why disease-linked mutants suffer from low RNA import and degradation activities
por: Golzarroshan, Bagher, et al.
Publicado: (2018)

Structural basis for the cooperative DNA recognition by Smad4 MH1 dimers
por: Baburajendran, Nithya, et al.
Publicado: (2011)

Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206
por: Liang, Yu, et al.
Publicado: (2012)

Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae
por: Boudes, Marion, et al.
Publicado: (2014)

Structural basis for the D-stereoselectivity of human DNA polymerase β
por: Vyas, Rajan, et al.
Publicado: (2017)

Structures of translationally inactive mammalian ribosomes
por: Brown, Alan, et al.
Publicado: (2018)

Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase
por: Ritacco, Christopher J., et al.
Publicado: (2013)

Structural basis of dimerization and dual W-box DNA recognition by rice WRKY domain
por: Cheng, Xiankun, et al.
Publicado: (2019)

Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk
por: Lee, Ka-Ming, et al.
Publicado: (2010)

Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu
por: Moon, Andrea F., et al.
Publicado: (2017)

Structural basis of DNA polymerase θ mediated DNA end joining
por: Li, Chuxuan, et al.
Publicado: (2022)

Structural basis for substrate recognition and cleavage by the dimerization-dependent CRISPR–Cas12f nuclease
por: Xiao, Renjian, et al.
Publicado: (2021)

Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1
por: Knott, Gavin J, et al.
Publicado: (2021)

Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t(6)A biosynthesis
por: Wan, Leo C.K., et al.
Publicado: (2016)

Structural mechanism of ATP-independent transcription initiation by RNA polymerase I
por: Han, Yan, et al.
Publicado: (2017)

The structural basis for partitioning of the XRCC1/DNA ligase III-α BRCT-mediated dimer complexes
por: Cuneo, Matthew J., et al.
Publicado: (2011)

Rbg1–Tma46 dimer structure reveals new functional domains and their role in polysome recruitment
por: Francis, Sandrea M., et al.
Publicado: (2012)

Collision events between RNA polymerases in convergent transcription studied by atomic force microscopy
por: Crampton, Neal, et al.
Publicado: (2006)

Visualizing the phage T4 activated transcription complex of DNA and E. coli RNA polymerase
por: James, Tamara D., et al.
Publicado: (2016)

Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors
por: Pflug, Alexander, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_pguq8vvc42ee91sskogtnfsftk