Antitumor effect of 4MU on glioblastoma cells is mediated by senescence induction and CD44, RHAMM and p-ERK modulation

The extracellular matrix plays a key role in cancer progression. Hyaluronan, the main glycosaminoglycan of the extracellular matrix, has been related to several tumor processes. Hyaluronan acts through the interaction with cell membrane receptors as CD44 and RHAMM and triggers signaling pathways as...

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Detalles Bibliográficos
Autores principales: Pibuel, Matías Arturo, Poodts, Daniela, Díaz, Mariángeles, Molinari, Yamila Azul, Franco, Paula Gabriela, Hajos, Silvia Elvira, Lompardía, Silvina Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502173/
https://www.ncbi.nlm.nih.gov/pubmed/34628469
http://dx.doi.org/10.1038/s41420-021-00672-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502173/
https://www.ncbi.nlm.nih.gov/pubmed/34628469
http://dx.doi.org/10.1038/s41420-021-00672-0

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