Cargando…

Oxy210, a novel inhibitor of hedgehog and TGF‐β signalling, ameliorates hepatic fibrosis and hypercholesterolemia in mice

AIMS: Non‐alcoholic steatohepatitis (NASH) is associated with increased overall morbidity and mortality in non‐alcoholic fatty liver disease (NAFLD) patients. Liver fibrosis is the strongest prognostic factor for clinical outcomes, liver‐related mortality and liver transplantation. Currently, no sin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hui, Simon T., Wang, Feng, Stappenbeck, Frank, French, Samuel W., Magyar, Clara E., Parhami, Farhad, Lusis, Aldons J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502222/ https://www.ncbi.nlm.nih.gov/pubmed/34505423 http://dx.doi.org/10.1002/edm2.296

Ejemplares similares

Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling
por: Stappenbeck, Frank, et al.
Publicado: (2019)

Oxy210, a Semi-Synthetic Oxysterol, Inhibits Profibrotic Signaling in Cellular Models of Lung and Kidney Fibrosis
por: Wang, Feng, et al.
Publicado: (2023)

Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization
por: Wang, Feng, et al.
Publicado: (2022)

Inhibition of Hedgehog Signaling in Fibroblasts, Pancreatic, and Lung Tumor Cells by Oxy186, an Oxysterol Analogue with Drug-Like Properties
por: Wang, Feng, et al.
Publicado: (2019)

Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer
por: Tang, Liu-Ya, et al.
Publicado: (2022)

Abstract P13. Oxy133, A Novel Osteogenic Agent, Promotes Bone Regeneration In The Rat Alveolar Cleft Model
por: Bakshi, Reena, et al.
Publicado: (2017)

The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice
por: Hui, Simon T., et al.
Publicado: (2018)

Empagliflozin suppresses hedgehog pathway, alleviates ER stress, and ameliorates hepatic fibrosis in rats
por: Abdalla, Nourihan, et al.
Publicado: (2023)

Maternal Low-Protein Diet or Hypercholesterolemia Reduces Circulating Essential Amino Acids and Leads to Intrauterine Growth Restriction
por: Bhasin, Kum Kum S., et al.
Publicado: (2009)

Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling
por: Hu, Yonghong, et al.
Publicado: (2022)

The Genetic Architecture of Carbon Tetrachloride-Induced Liver Fibrosis in Mice
por: Tuominen, Iina, et al.
Publicado: (2020)

Dendropanax morbifera Ameliorates Thioacetamide-Induced Hepatic Fibrosis via TGF-β1/Smads Pathways
por: Yang, Hun Yong, et al.
Publicado: (2019)

Black ginseng extract ameliorates hypercholesterolemia in rats
por: Saba, Evelyn, et al.
Publicado: (2016)

Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice
por: Hui, Simon T., et al.
Publicado: (2023)

Fermented Garlic Ameliorates Hypercholesterolemia and Inhibits Platelet Activation
por: Irfan, Muhammad, et al.
Publicado: (2019)

Coagulation factor with potential for the treatment of heart failure
por: Cao, Yang, et al.
Publicado: (2022)

Hedgehog Signaling in Pancreatic Fibrosis and Cancer
por: Bai, Yongyu, et al.
Publicado: (2016)

The total polyphenolic glycoside extract of Lamiophlomis rotata ameliorates hepatic fibrosis through apoptosis by TGF-β/Smad signaling pathway
por: Wan, Guoguo, et al.
Publicado: (2023)

A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells
por: Kasahara, Nanaho, et al.
Publicado: (2023)

Systems-based approaches for investigation of inter-tissue communication
por: Seldin, Marcus M., et al.
Publicado: (2019)

Multi-omics approaches to disease
por: Hasin, Yehudit, et al.
Publicado: (2017)

Magnesium Isoglycyrrhizinate Ameliorates Fibrosis and Disrupts TGF-β-Mediated SMAD Pathway in Activated Hepatic Stellate Cell Line LX2
por: Tee, Jie Kai, et al.
Publicado: (2018)

(226)Ra, (210)Pb, (210)Bi and (210)Po deposition and removal from surfaces and liquids
por: Wójcik, M., et al.
Publicado: (2012)

Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-β Signal Pathway
por: Ren, Xianguo, et al.
Publicado: (2016)

Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF-β1 Signaling Pathway
por: Li, Xiaohe, et al.
Publicado: (2021)

Counteracting stem cell expansion during wound repair: Distinct roles of non-canonical Wnt and TGF-β
por: Miyoshi, Hiroyuki, et al.
Publicado: (2013)

Polysaccharides extracted from balanophora polyandra Griff (BPP) ameliorate renal Fibrosis and EMT via inhibiting the Hedgehog pathway
por: Li, Luoying, et al.
Publicado: (2021)

Osthole ameliorates hepatic fibrosis and inhibits hepatic stellate cell activation
por: Liu, Ya-Wei, et al.
Publicado: (2015)

microRNA-483 ameliorates hypercholesterolemia by inhibiting PCSK9 production
por: Dong, Jianjie, et al.
Publicado: (2020)

NDRG2 Ameliorates Hepatic Fibrosis by Inhibiting the TGF-β1/Smad Pathway and Altering the MMP2/TIMP2 Ratio in Rats
por: Yang, Jiandong, et al.
Publicado: (2011)

Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice
por: Ishikawa, Kazunobu, et al.
Publicado: (2012)

Tribute to Dr. Steve Schwartz
por: Lusis, Aldons J., et al.
Publicado: (2020)

Sorafenib Ameliorates Renal Fibrosis through Inhibition of TGF-β-Induced Epithelial-Mesenchymal Transition
por: Jia, Lining, et al.
Publicado: (2015)

Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway
por: Saito, Shigeki, et al.
Publicado: (2017)

Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1/Smads Signaling Pathway
por: Chen, Hongshu, et al.
Publicado: (2017)

The decay of $^{210}_{86}$Rn$_{124}$ to levels in $^{210}_{85}$At$_{125}$
por: Jonson, B, et al.
Publicado: (1972)

Roles of Macrophages in Atherogenesis
por: Farahi, Lia, et al.
Publicado: (2021)

Transition probabilities of low-lying excited states in 210Po and 210Pb
por: Georgiev, Georgi, et al.
Publicado: (2022)

Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis
por: Luong, Vu Huy, et al.
Publicado: (2018)

Curdione ameliorates bleomycin-induced pulmonary fibrosis by repressing TGF-β-induced fibroblast to myofibroblast differentiation
por: Liu, Peng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9k88hc0jjg7jcp60rbbain18s1