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Telomere shortening causes distinct cell division regimes during replicative senescence in Saccharomyces cerevisiae

BACKGROUND: Telomerase-negative cells have limited proliferation potential. In these cells, telomeres shorten until they reach a critical length and induce a permanently arrested state. This process called replicative senescence is associated with genomic instability and participates in tissue and o...

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Detalles Bibliográficos
Autores principales: Martin, Hugo, Doumic, Marie, Teixeira, Maria Teresa, Xu, Zhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502270/
https://www.ncbi.nlm.nih.gov/pubmed/34627377
http://dx.doi.org/10.1186/s13578-021-00693-3