Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers

This study examined the safety, tolerability, and pharmacokinetics (PK) of napabucasin in healthy Asian and non‐Asian participants and investigated the potential for QT/QTc interval prolongation. This five‐part (A–E) study proceeded in a stepwise manner, unless stopping criteria were met. Parts A–D...

Descripción completa

Detalles Bibliográficos
Autores principales: Noda, Naoto, Takagaki, Takeshi, Yodo, Yasuhide, Horibuchi, Yuzo, Iino, Shuichi, Matsuki, Shunji, Ogama, Yoichiro, Kakuyama, Hiroyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502439/
https://www.ncbi.nlm.nih.gov/pubmed/34628720
http://dx.doi.org/10.1002/prp2.874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502439/
https://www.ncbi.nlm.nih.gov/pubmed/34628720
http://dx.doi.org/10.1002/prp2.874

Ejemplares similares