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Effects of a reactive oxygen species generator, napabucasin (BBI608), on tolerability, safety, pharmacokinetics, and QT/QTc interval in healthy volunteers

This study examined the safety, tolerability, and pharmacokinetics (PK) of napabucasin in healthy Asian and non‐Asian participants and investigated the potential for QT/QTc interval prolongation. This five‐part (A–E) study proceeded in a stepwise manner, unless stopping criteria were met. Parts A–D...

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Detalles Bibliográficos
Autores principales:	Noda, Naoto, Takagaki, Takeshi, Yodo, Yasuhide, Horibuchi, Yuzo, Iino, Shuichi, Matsuki, Shunji, Ogama, Yoichiro, Kakuyama, Hiroyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502439/ https://www.ncbi.nlm.nih.gov/pubmed/34628720 http://dx.doi.org/10.1002/prp2.874

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