ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

Viral entry and egress are important determinants of virus infectivity and pathogenicity. β-coronaviruses, including the COVID-19 virus SARS-CoV-2 and mouse hepatitis virus (MHV), exploit the lysosomal exocytosis pathway for egress. Here, we show that SARS-CoV-2 ORF3a, but not SARS-CoV ORF3a, promot...

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Detalles Bibliográficos
Autores principales: Chen, Di, Zheng, Qiaoxia, Sun, Long, Ji, Mingming, Li, Yan, Deng, Hongyu, Zhang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502680/
https://www.ncbi.nlm.nih.gov/pubmed/34706264
http://dx.doi.org/10.1016/j.devcel.2021.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502680/
https://www.ncbi.nlm.nih.gov/pubmed/34706264
http://dx.doi.org/10.1016/j.devcel.2021.10.006

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