A C terminus–dependent conformational change is required for HDAC3 activation by nuclear receptor corepressors

Histone deacetylase 3 (HDAC3) plays an important role in signal-dependent transcription and is dysregulated in diseases such as cancer. Previous studies have shown that the function of HDAC3 requires an activation step, which is mediated by the interactions of HDAC3 with the deacetylase-activation d...

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Detalles Bibliográficos
Autores principales: Li, Jian, Guo, Chun, Rood, Christopher, Zhang, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502911/
https://www.ncbi.nlm.nih.gov/pubmed/34520758
http://dx.doi.org/10.1016/j.jbc.2021.101192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502911/
https://www.ncbi.nlm.nih.gov/pubmed/34520758
http://dx.doi.org/10.1016/j.jbc.2021.101192

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