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A C terminus–dependent conformational change is required for HDAC3 activation by nuclear receptor corepressors
Histone deacetylase 3 (HDAC3) plays an important role in signal-dependent transcription and is dysregulated in diseases such as cancer. Previous studies have shown that the function of HDAC3 requires an activation step, which is mediated by the interactions of HDAC3 with the deacetylase-activation d...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502911/ https://www.ncbi.nlm.nih.gov/pubmed/34520758 http://dx.doi.org/10.1016/j.jbc.2021.101192 |