Cargando…

An Advanced Systems Pharmacology Strategy Reveals AKR1B1, MMP2, PTGER3 as Key Genes in the Competing Endogenous RNA Network of Compound Kushen Injection Treating Gastric Carcinoma by Integrated Bioinformatics and Experimental Verification

Gastric carcinoma (GC) is a severe tumor of the digestive tract with high morbidity and mortality and poor prognosis, for which novel treatment options are urgently needed. Compound Kushen injection (CKI), a classical injection of Chinese medicine, has been widely used to treat various tumors in cli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Wei, Wu, Chao, Zhao, Chongjun, Huang, Zhihong, Lu, Shan, Fan, Xiaotian, Tan, Yingying, Stalin, Antony, You, Rongli, Liu, Xinkui, Zhang, Jingyuan, Wu, Zhishan, Wu, Jiarui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502965/ https://www.ncbi.nlm.nih.gov/pubmed/34646828 http://dx.doi.org/10.3389/fcell.2021.742421

Ejemplares similares

An advanced network pharmacology study to explore the novel molecular mechanism of Compound Kushen Injection for treating hepatocellular carcinoma by bioinformatics and experimental verification
por: Lu, Shan, et al.
Publicado: (2022)

A New Strategy to Identify ceRNA-Based CCDC144NL-AS1/SERPINE1 Regulatory Axis as a Novel Prognostic Biomarker for Stomach Adenocarcinoma via High Throughput Transcriptome Data Mining and Computational Verification
por: Huang, Zhihong, et al.
Publicado: (2022)

High Throughput Transcriptome Data Analysis and Computational Verification Reveal Immunotherapy Biomarkers of Compound Kushen Injection for Treating Triple-Negative Breast Cancer
por: Liu, Xinkui, et al.
Publicado: (2021)

Integrated network pharmacology analysis and in vitro validation revealed the underlying mechanism of Xiyanping injection in treating coronavirus disease 2019
por: Li, Jialin, et al.
Publicado: (2023)

Study on the mechanisms of compound Kushen injection for the treatment of gastric cancer based on network pharmacology
por: Zhou, Wei, et al.
Publicado: (2020)

Data mining combines bioinformatics discover immunoinfiltration-related gene SERPINE1 as a biomarker for diagnosis and prognosis of stomach adenocarcinoma
por: Zhai, Yiyan, et al.
Publicado: (2023)

Identification of an immune-related 6-lncRNA panel with a good performance for prognostic prediction in hepatocellular carcinoma by integrated bioinformatics analysis
por: Lu, Shan, et al.
Publicado: (2023)

A Bioinformatics Research on Novel Mechanism of Compound Kushen Injection for Treating Breast Cancer by Network Pharmacology and Molecular Docking Verification
por: Liu, Shuyu, et al.
Publicado: (2020)

Single-cell RNA-sequencing uncovers compound kushen injection synergistically improves the efficacy of chemotherapy by modulating the tumor environment of breast cancer
por: Liu, Xinkui, et al.
Publicado: (2022)

Integrated bioinformatics analysis to decipher molecular mechanism of compound Kushen injection for esophageal cancer by combining WGCNA with network pharmacology
por: Zhou, Wei, et al.
Publicado: (2020)

Exploring the Multicomponent Synergy Mechanism of Yinzhihuang Granule in Inhibiting Inflammation-Cancer Transformation of Hepar Based on Integrated Bioinformatics and Network Pharmacology
por: Zhang, Jingyuan, et al.
Publicado: (2022)

Identification of molecular mechanisms underlying the therapeutic effects of Xintong granule in coronary artery disease by a network pharmacology and molecular docking approach
por: Huang, Zhihong, et al.
Publicado: (2022)

Mechanisms of Compound Kushen Injection for the Treatment of Lung Cancer Based on Network Pharmacology
por: Meng, Ziqi, et al.
Publicado: (2019)

Revealing Calcium Signaling Pathway as Novel Mechanism of Danhong Injection for Treating Acute Myocardial Infarction by Systems Pharmacology and Experiment Validation
por: Guo, Siyu, et al.
Publicado: (2022)

Single-Cell and Bulk RNA Sequencing Reveal Malignant Epithelial Cell Heterogeneity and Prognosis Signatures in Gastric Carcinoma
por: Huang, Zhihong, et al.
Publicado: (2022)

PTGER3 and MMP-2 play potential roles in diabetic nephropathy via competing endogenous RNA mechanisms
por: Yu, Yue, et al.
Publicado: (2021)

Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network Pharmacology
por: Liu, Yingying, et al.
Publicado: (2022)

Corrigendum: Revealing the mechanism of Huazhi Rougan granule in the treatment of nonalcoholic fatty liver through intestinal flora based on 16S rRNA, metagenomic sequencing and network pharmacology
por: Liu, Yingying, et al.
Publicado: (2023)

A Multidimensional Bayesian Network Meta-Analysis of Chinese Herbal Injections for Treating Non-small Cell Lung Cancer With Gemcitabine and Cisplatin
por: Ni, Mengwei, et al.
Publicado: (2021)

Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking
por: Tan, Yingying, et al.
Publicado: (2023)

Correction: Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking
por: Tan, Yingying, et al.
Publicado: (2023)

Exploring potential mechanisms of Suhexiang Pill against COVID-19 based on network pharmacology and molecular docking
por: Li, Jialin, et al.
Publicado: (2021)

Dissecting the novel mechanism of reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification
por: Jia, Shanshan, et al.
Publicado: (2021)

A bioinformatics investigation into molecular mechanism of Yinzhihuang granules for treating hepatitis B by network pharmacology and molecular docking verification
por: Zhang, Jingyuan, et al.
Publicado: (2020)

Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer
por: Yu, Shuyong, et al.
Publicado: (2023)

PTGER1 and PTGER2 receptors mediate regulation of progesterone synthesis and type 1 11β-hydroxysteroid dehydrogenase activity by prostaglandin E(2) in human granulosa–lutein cells
por: Chandras, C, et al.
Publicado: (2007)

Investigation on the mechanisms of guiqi huoxue capsule for treating cervical spondylosis based on network pharmacology and molecular docking
por: Liu, Yingying, et al.
Publicado: (2021)

Maternal and Fetal Genetic Associations of PTGER3 and PON1 with Preterm Birth
por: Ryckman, Kelli K., et al.
Publicado: (2010)

Enzymes of the AKR1B and AKR1C Subfamilies and Uterine Diseases
por: Rižner, Tea Lanišnik
Publicado: (2012)

Identification of Key Genes Associated With the Process of Hepatitis B Inflammation and Cancer Transformation by Integrated Bioinformatics Analysis
por: Zhang, Jingyuan, et al.
Publicado: (2021)

Lactoferrin Alleviates Lipopolysaccharide-Induced Infantile Intestinal Immune Barrier Damage by Regulating an ELAVL1-Related Signaling Pathway
por: Li, Chaonan, et al.
Publicado: (2022)

Antitumor Activities of Kushen: Literature Review
por: Sun, Mingyu, et al.
Publicado: (2012)

Expression of the Aldo-Ketoreductases AKR1B1 and AKR1B10 in Human Cancers
por: Laffin, Brian, et al.
Publicado: (2012)

Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma
por: Zhu, Pengfei, et al.
Publicado: (2021)

AKR1B1 and AKR1B10 as Prognostic Biomarkers of Endometrioid Endometrial Carcinomas
por: Hojnik, Marko, et al.
Publicado: (2021)

Compound Kushen Injection for gastric cancer: A protocol of systematic review and meta-analysis
por: Huang, Zhihong, et al.
Publicado: (2019)

Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib
por: Yang, Yang, et al.
Publicado: (2020)

Maternal Protein Restriction Alters the Renal Ptger1 DNA Methylation State in SHRSP Offspring
por: Miyoshi, Moe, et al.
Publicado: (2018)

Investigation on the efficiency of Brucea javanica oil emulsion injection with chemotherapy for treating malignant pleural effusion: A meta-analysis of randomized controlled trials
por: Shi, Rui, et al.
Publicado: (2022)

Identification of key pharmacological components and targets for Aidi injection in the treatment of pancreatic cancer by UPLC-MS, network pharmacology, and in vivo experiments
por: Wang, Haojia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4f50kjqfhb7s9v13du06n5tnf1