Sonic Hedgehog Induces Mesenchymal Stromal Cell Senescence-Associated Secretory Phenotype and Chondrocyte Apoptosis in Human Osteoarthritic Cartilage

Hedgehog (HH) signaling plays a critical role in osteoarthritis (OA) pathogenesis, but the molecular mechanism remains to be elucidated. We show here that Sonic Hedgehog (SHH) gene expression is initiated in human normal cartilage stromal cells (NCSC) and increased in OA cartilage mesenchymal stroma...

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Detalles Bibliográficos
Autores principales: Feng, Meng, Liu, Wenguang, Ding, Jing, Qiu, Yusheng, Chen, Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502980/
https://www.ncbi.nlm.nih.gov/pubmed/34646822
http://dx.doi.org/10.3389/fcell.2021.716610

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8502980/
https://www.ncbi.nlm.nih.gov/pubmed/34646822
http://dx.doi.org/10.3389/fcell.2021.716610

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