Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin

Previous studies have shown that agonists of GPR17 stimulate, while antagonists inhibit feeding. However, whole body knockout of GPR17 in mice of the C57Bl/6 strain did not affect energy balance, whereas selective knockout in oligodendrocytes or pro-opiomelanocortin neurons provided protection from...

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Detalles Bibliográficos
Autores principales: Wargent, Edward T., Ahmad, Suhaib J. S., Lu, Qing Richard, Kostenis, Evi, Arch, Jonathan R. S., Stocker, Claire J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503278/
https://www.ncbi.nlm.nih.gov/pubmed/34646232
http://dx.doi.org/10.3389/fendo.2021.698115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503278/
https://www.ncbi.nlm.nih.gov/pubmed/34646232
http://dx.doi.org/10.3389/fendo.2021.698115

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