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Crystal structure of human cysteamine dioxygenase provides a structural rationale for its function as an oxygen sensor

Cysteamine dioxygenase (ADO) plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis in humans by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O(2) as a cosubstrate. However, as the only thiol d...

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Detalles Bibliográficos
Autores principales: Shin, Inchul, Li, Jiasong, Liu, Aimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503633/
https://www.ncbi.nlm.nih.gov/pubmed/34508780
http://dx.doi.org/10.1016/j.jbc.2021.101176