relA Inactivation Converts Sulfonamides Into Bactericidal Compounds

Folates are required for the de novo biosynthesis of purines, thymine, methionine, glycine, and pantothenic acid, key metabolites that bacterial cells cannot survive without. Sulfonamides, which inhibit bacterial folate biosynthesis and are generally considered as bacteriostats, have been extensivel...

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Detalles Bibliográficos
Autores principales: Si, Lizhen, Gu, Jing, Wen, Mi, Wang, Ruiqi, Fleming, Joy, Li, Jinyue, Xu, Jintian, Bi, Lijun, Deng, Jiaoyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503649/
https://www.ncbi.nlm.nih.gov/pubmed/34646242
http://dx.doi.org/10.3389/fmicb.2021.698468

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503649/
https://www.ncbi.nlm.nih.gov/pubmed/34646242
http://dx.doi.org/10.3389/fmicb.2021.698468

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