Local adenoviral delivery of soluble CD200R-Ig enhances antitumor immunity by inhibiting CD200-β-catenin-driven M2 macrophage

CD200 is known as an immune checkpoint molecule that inhibits innate immune cell activation. Using a head and neck squamous cell carcinoma (HNSCC) model, we sought to determine whether localized delivery of adenovirus-expressing sCD200R1-Ig, the soluble extracellular domain of CD200R1, enhances anti...

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Detalles Bibliográficos
Autores principales: Shin, Seung-Phil, Goh, A-Ra, Ju, Ji-Min, Kang, Hyeon-Gu, Kim, Seok-Jun, Kim, Jong-Kwang, Park, Eun-Jung, Bae, Yong-Soo, Choi, Kyungho, Jung, Yuh-Seog, Lee, Sang-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503857/
https://www.ncbi.nlm.nih.gov/pubmed/34703882
http://dx.doi.org/10.1016/j.omto.2021.09.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503857/
https://www.ncbi.nlm.nih.gov/pubmed/34703882
http://dx.doi.org/10.1016/j.omto.2021.09.001

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