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Coiled coils 9-to-5: rational de novo design of α-helical barrels with tunable oligomeric states
The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures and avoid alternative states. However, the non-covalent forces that stabilize and discriminate between states are weak. Nonetheless, for α-h...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503928/ https://www.ncbi.nlm.nih.gov/pubmed/34745518 http://dx.doi.org/10.1039/d1sc00460c |