Cargando…
Coiled coils 9-to-5: rational de novo design of α-helical barrels with tunable oligomeric states
The rational design of linear peptides that assemble controllably and predictably in water is challenging. Short sequences must encode unique target structures and avoid alternative states. However, the non-covalent forces that stabilize and discriminate between states are weak. Nonetheless, for α-h...
Autores principales: | Dawson, William M., Martin, Freddie J. O., Rhys, Guto G., Shelley, Kathryn L., Brady, R. Leo, Woolfson, Derek N. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8503928/ https://www.ncbi.nlm.nih.gov/pubmed/34745518 http://dx.doi.org/10.1039/d1sc00460c |
Ejemplares similares
-
Molecular Mechanism of STIL Coiled-Coil Domain Oligomerization
por: Shamir, Mai, et al.
Publicado: (2023) -
De novo coiled-coil peptides as scaffolds for disrupting protein–protein interactions
por: Fletcher, Jordan M., et al.
Publicado: (2018) -
Maintaining and breaking symmetry in homomeric coiled-coil assemblies
por: Rhys, Guto G., et al.
Publicado: (2018) -
Rational Design
of Phosphorylation-Responsive Coiled
Coil-Peptide Assemblies
por: Thompson, Harry F., et al.
Publicado: (2023) -
Structural resolution of switchable states of a de novo peptide assembly
por: Dawson, William M., et al.
Publicado: (2021)