Upregulation of Thymidylate Synthase Induces Pemetrexed Resistance in Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is an invasive malignancy that develops in the pleural cavity, and antifolates are used as chemotherapeutics for treating. The majority of antifolates, including pemetrexed (PMX), inhibit enzymes involved in purine and pyrimidine synthesis. MPM patients frequentl...

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Detalles Bibliográficos
Autores principales: Sato, Yuzo, Tomita, Masaru, Soga, Tomoyoshi, Ochiai, Atsushi, Makinoshima, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504579/
https://www.ncbi.nlm.nih.gov/pubmed/34646134
http://dx.doi.org/10.3389/fphar.2021.718675

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504579/
https://www.ncbi.nlm.nih.gov/pubmed/34646134
http://dx.doi.org/10.3389/fphar.2021.718675

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