Translational and pharmacokinetic‐pharmacodynamic application for the clinical development of GDC‐0334, a novel TRPA1 inhibitor

GDC‐0334 is a novel small molecule inhibitor of transient receptor potential cation channel member A1 (TRPA1), a promising therapeutic target for many nervous system and respiratory diseases. The pharmacokinetic (PK) profile and pharmacodynamic (PD) effects of GDC‐0334 were evaluated in this first‐i...

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Detalles Bibliográficos
Autores principales: Chan, Phyllis, Ding, Han Ting, Liederer, Bianca M., Mao, Jialin, Belloni, Paula, Chen, Liuxi, Gao, Simon S., Joseph, Victory, Yang, Xiaoying, Lin, Joseph S., Mitra, Mayur S., Putnam, Wendy S., Quartino, Angelica, Bauer, Rebecca N., Pan, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504827/
https://www.ncbi.nlm.nih.gov/pubmed/34058071
http://dx.doi.org/10.1111/cts.13049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504827/
https://www.ncbi.nlm.nih.gov/pubmed/34058071
http://dx.doi.org/10.1111/cts.13049

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