3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and simulate the rich environment and complex processes observed in...

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Detalles Bibliográficos
Autores principales: Wang, Hongbing, Brown, Paul C., Chow, Edwin C.Y., Ewart, Lorna, Ferguson, Stephen S., Fitzpatrick, Suzanne, Freedman, Benjamin S., Guo, Grace L., Hedrich, William, Heyward, Scott, Hickman, James, Isoherranen, Nina, Li, Albert P., Liu, Qi, Mumenthaler, Shannon M., Polli, James, Proctor, William R., Ribeiro, Alexandre, Wang, Jian‐Ying, Wange, Ronald L., Huang, Shiew‐Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504835/
https://www.ncbi.nlm.nih.gov/pubmed/33982436
http://dx.doi.org/10.1111/cts.13066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8504835/
https://www.ncbi.nlm.nih.gov/pubmed/33982436
http://dx.doi.org/10.1111/cts.13066

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