Cargando…
Low-dose metronomic doxorubicin inhibits mobilization and differentiation of endothelial progenitor cells through REDD1-mediated VEGFR-2 downregulation
Low-dose metronomic chemotherapy has been introduced as a less toxic and effective strategy to inhibit tumor angiogenesis, but its anti-angiogenic mechanism on endothelial progenitor cells (EPCs) has not been fully elucidated. Here, we investigated the functional role of regulated in development and...
Autores principales: | Park, Minsik, Kim, Ji Yoon, Kim, Joohwan, Lee, Jeong-Hyung, Kwon, Young-Guen, Kim, Young-Myeong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505230/ https://www.ncbi.nlm.nih.gov/pubmed/34488932 http://dx.doi.org/10.5483/BMBRep.2021.54.9.096 |
Ejemplares similares
-
REDD1 is a determinant of low-dose metronomic doxorubicin-elicited endothelial cell dysfunction through downregulation of VEGFR-2/3 expression
por: Park, Minsik, et al.
Publicado: (2021) -
REDD1 promotes obesity-induced metabolic dysfunction via atypical NF-κB activation
por: Lee, Dong-Keon, et al.
Publicado: (2022) -
The stress-responsive protein REDD1 and its pathophysiological functions
por: Kim, Ji-Yoon, et al.
Publicado: (2023) -
NF-κB-dependent miR-31/155 biogenesis is essential for TNF-α-induced impairment of endothelial progenitor cell function
por: Kim, Ji-Hee, et al.
Publicado: (2020) -
SALM4 regulates angiogenic functions in endothelial cells through VEGFR2 phosphorylation at Tyr1175
por: Kim, Dong Young, et al.
Publicado: (2019)