Estimation of Clearance and Bioavailability of Therapeutic Monoclonal Antibodies from Only Subcutaneous Injection Data in Humans Based on Comprehensive Analysis of Clinical Data

INTRODUCTION: Theoretically, the separate estimation of clearance (CL) and bioavailability (F) requires both intravenous and extravascular injection data. This study investigated whether CL and subcutaneous F of therapeutic monoclonal antibodies (mAbs) in humans can be separately estimated from subc...

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Detalles Bibliográficos
Autores principales: Haraya, Kenta, Tachibana, Tatsuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505369/
https://www.ncbi.nlm.nih.gov/pubmed/33954956
http://dx.doi.org/10.1007/s40262-021-01023-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505369/
https://www.ncbi.nlm.nih.gov/pubmed/33954956
http://dx.doi.org/10.1007/s40262-021-01023-z

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