HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

DNA damage is increased in Alzheimer’s disease (AD), while the underlying mechanisms are unknown. Here, we employ comprehensive phosphoproteome analysis, and identify abnormal phosphorylation of 70 kDa subunit of Ku antigen (Ku70) at Ser77/78, which prevents Ku70-DNA interaction, in human AD postmor...

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Detalles Bibliográficos
Autores principales: Tanaka, Hikari, Kondo, Kanoh, Fujita, Kyota, Homma, Hidenori, Tagawa, Kazuhiko, Jin, Xiaocen, Jin, Meihua, Yoshioka, Yuki, Takayama, Sumire, Masuda, Hitomi, Tokuyama, Rie, Nakazaki, Yukoh, Saito, Takashi, Saido, Takaomi, Murayama, Shigeo, Ikura, Teikichi, Ito, Nobutoshi, Yamamori, Yu, Tomii, Kentaro, Bianchi, Marco E., Okazawa, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505418/
https://www.ncbi.nlm.nih.gov/pubmed/34635772
http://dx.doi.org/10.1038/s42003-021-02671-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505418/
https://www.ncbi.nlm.nih.gov/pubmed/34635772
http://dx.doi.org/10.1038/s42003-021-02671-4

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