Sitagliptin activates the p62–Keap1–Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury

Acute lung injury (ALI) is a complication of severe acute pancreatitis (SAP). Sitagliptin (SIT) is a DPP4 inhibitor that exerts anti-inflammatory and antioxidant effects; however, its mechanism of action in SAP-ALI remains unclear. In this study, we investigated the effects of SIT on SAP-ALI and the...

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Detalles Bibliográficos
Autores principales: Kong, Lingming, Deng, Jie, Zhou, Xiang, Cai, Binbin, Zhang, Baofu, Chen, Xiaohu, Chen, Zongjing, Wang, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505515/
https://www.ncbi.nlm.nih.gov/pubmed/34635643
http://dx.doi.org/10.1038/s41419-021-04227-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505515/
https://www.ncbi.nlm.nih.gov/pubmed/34635643
http://dx.doi.org/10.1038/s41419-021-04227-0

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