Peripheral Hybrid CB(1)R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis

Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB(1)R) and increased activity of inducible NO synthase (iNOS) promote tissue fibrosis...

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Detalles Bibliográficos
Autores principales: Zawatsky, Charles N., Park, Joshua K., Abdalla, Jasmina, Kunos, George, Iyer, Malliga R., Cinar, Resat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505776/
https://www.ncbi.nlm.nih.gov/pubmed/34650521
http://dx.doi.org/10.3389/fendo.2021.744857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505776/
https://www.ncbi.nlm.nih.gov/pubmed/34650521
http://dx.doi.org/10.3389/fendo.2021.744857

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