Impaired non‐canonical transforming growth factor‐β signalling prevents profibrotic phenotypes in cultured peptidylarginine deiminase 4‐deficient murine cardiac fibroblasts

Transforming growth factor‐β (TGF‐β) becomes rapidly activated in the infarcted heart. Hence, TGF‐β‐mediated persistent activation of cardiac fibroblasts (CFs) and exaggerated fibrotic responses may result in adverse cardiac remodelling and heart failure. Additionally, peptidylarginine deiminase 4 (...

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Detalles Bibliográficos
Autores principales: Akboua, Hanane, Eghbalzadeh, Kaveh, Keser, Ugur, Wahlers, Thorsten, Paunel‐Görgülü, Adnana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505821/
https://www.ncbi.nlm.nih.gov/pubmed/34523218
http://dx.doi.org/10.1111/jcmm.16915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505821/
https://www.ncbi.nlm.nih.gov/pubmed/34523218
http://dx.doi.org/10.1111/jcmm.16915

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