The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells

In approximately 15% of patients with acute myeloid leukemia (AML), total and phosphorylated EGFR proteins have been reported to be increased compared to healthy CD34(+) samples. However, it is unclear if this subset of patients would benefit from EGFR signaling pharmacological inhibition. Pre-clini...

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Detalles Bibliográficos
Autores principales: de Almeida, Luciana Yamamoto, Pereira-Martins, Diego A., Weinhäuser, Isabel, Ortiz, César, Cândido, Larissa A., Lange, Ana Paula, De Abreu, Nayara F., Mendonza, Sílvia E. S., de Deus Wagatsuma, Virgínia M., Do Nascimento, Mariane C., Paiva, Helder H., Alves-Paiva, Raquel M., Bonaldo, Camila C. O. M., Nascimento, Daniele C., Alves-Filho, José C., Scheucher, Priscila S., Lima, Ana Sílvia G., Schuringa, Jan Jacob, Ammantuna, Emanuele, Ottone, Tiziana, Noguera, Nelida I., Araujo, Cleide L., Rego, Eduardo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506138/
https://www.ncbi.nlm.nih.gov/pubmed/34650910
http://dx.doi.org/10.3389/fonc.2021.686445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506138/
https://www.ncbi.nlm.nih.gov/pubmed/34650910
http://dx.doi.org/10.3389/fonc.2021.686445

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