Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation

[Image: see text] Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon contributes to withdrawal symptoms, hyperalgesia and analgesi...

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Detalles Bibliográficos
Autores principales: Mansour, Ahmed, Nagi, Karim, Dallaire, Paul, Lukasheva, Viktoriya, Le Gouill, Christian, Bouvier, Michel, Pineyro, Graciela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506601/
https://www.ncbi.nlm.nih.gov/pubmed/34661070
http://dx.doi.org/10.1021/acsptsci.1c00019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506601/
https://www.ncbi.nlm.nih.gov/pubmed/34661070
http://dx.doi.org/10.1021/acsptsci.1c00019

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