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Comprehensive Signaling Profiles Reveal Unsuspected Functional Selectivity of δ-Opioid Receptor Agonists and Allow the Identification of Ligands with the Greatest Potential for Inducing Cyclase Superactivation
[Image: see text] Prolonged exposure to opioid receptor agonists triggers adaptations in the adenylyl cyclase (AC) pathway that lead to enhanced production of cyclic adenosine monophosphate (cAMP) upon withdrawal. This cellular phenomenon contributes to withdrawal symptoms, hyperalgesia and analgesi...
Autores principales: | Mansour, Ahmed, Nagi, Karim, Dallaire, Paul, Lukasheva, Viktoriya, Le Gouill, Christian, Bouvier, Michel, Pineyro, Graciela |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8506601/ https://www.ncbi.nlm.nih.gov/pubmed/34661070 http://dx.doi.org/10.1021/acsptsci.1c00019 |
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