Neuronal excitatory-to-inhibitory balance is altered in cerebral organoid models of genetic neurological diseases

The neuro-physiological properties of individuals with genetic pre-disposition to neurological disorders are largely unknown. Here we aimed to explore these properties using cerebral organoids (COs) derived from fibroblasts of individuals with confirmed genetic mutations including PRNP(E200K), triso...

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Detalles Bibliográficos
Autores principales: Foliaki, Simote T., Schwarz, Benjamin, Groveman, Bradley R., Walters, Ryan O., Ferreira, Natalia C., Orrù, Christina D., Smith, Anna, Wood, Aleksandar, Schmit, Olivia M., Freitag, Phoebe, Yuan, Jue, Zou, Wenquan, Bosio, Catharine M., Carroll, James A., Haigh, Cathryn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507222/
https://www.ncbi.nlm.nih.gov/pubmed/34635127
http://dx.doi.org/10.1186/s13041-021-00864-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507222/
https://www.ncbi.nlm.nih.gov/pubmed/34635127
http://dx.doi.org/10.1186/s13041-021-00864-w

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