Titratable Pharmacological Regulation of CAR T Cells Using Zinc Finger-Based Transcription Factors

SIMPLE SUMMARY: Chimeric antigen receptor (CAR) T cell therapy can be associated with substantial side effects primarily due to intense immune activation following treatment, or target antigen recognition on off-tumor tissue. Consequently, temporal and tunable control of CAR T cell activity is of ma...

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Detalles Bibliográficos
Autores principales: Kotter, Bettina, Engert, Fabian, Krueger, Winfried, Roy, Andre, Rawashdeh, Wael Al, Cordes, Nicole, Drees, Britta, Webster, Brian, Werchau, Niels, Lock, Dominik, Dapa, Sandra, Schneider, Dina, Ludwig, Stephan, Rossig, Claudia, Assenmacher, Mario, Mittelstaet, Joerg, Kaiser, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507528/
https://www.ncbi.nlm.nih.gov/pubmed/34638227
http://dx.doi.org/10.3390/cancers13194741

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507528/
https://www.ncbi.nlm.nih.gov/pubmed/34638227
http://dx.doi.org/10.3390/cancers13194741

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