Poly(ADP)-Ribosylation Inhibition: A Promising Approach for Clear Cell Renal Cell Carcinoma Therapy

SIMPLE SUMMARY: We have shown that Clear Cell Renal Cell Carcinoma (ccRCC) is prone to accumulate poly(ADPribose) due to increase in PARP-1 and decrease in PARG enzymes. Reduction of pADPr by PARP-1 inhibition or PARG overexpression disrupts renal carcinoma cell malignancy. We have shown that ccRCC...

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Detalles Bibliográficos
Autores principales: Karpova, Yaroslava, Guo, Danping, Makhov, Peter, Haines, Adam M., Markov, Dmitriy A., Kolenko, Vladimir, Tulin, Alexei V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507656/
https://www.ncbi.nlm.nih.gov/pubmed/34638458
http://dx.doi.org/10.3390/cancers13194973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507656/
https://www.ncbi.nlm.nih.gov/pubmed/34638458
http://dx.doi.org/10.3390/cancers13194973

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