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Poly(ADP)-Ribosylation Inhibition: A Promising Approach for Clear Cell Renal Cell Carcinoma Therapy
SIMPLE SUMMARY: We have shown that Clear Cell Renal Cell Carcinoma (ccRCC) is prone to accumulate poly(ADPribose) due to increase in PARP-1 and decrease in PARG enzymes. Reduction of pADPr by PARP-1 inhibition or PARG overexpression disrupts renal carcinoma cell malignancy. We have shown that ccRCC...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507656/ https://www.ncbi.nlm.nih.gov/pubmed/34638458 http://dx.doi.org/10.3390/cancers13194973 |