The FHP01 DDX3X Helicase Inhibitor Exerts Potent Anti-Tumor Activity In Vivo in Breast Cancer Pre-Clinical Models

SIMPLE SUMMARY: DDX3X has been repeatedly proven to exert pro-tumorigenic effects in breast cancer. An inhibitor of DDX3X helicase function, FHP01, exhibited very effective antiproliferative and tumor killing activity in vitro and in vivo against several breast cancer cells, yet showed no systemic t...

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Detalles Bibliográficos
Autores principales: Gherardini, Lisa, Inzalaco, Giovanni, Imperatore, Francesco, D’Aurizio, Romina, Franci, Lorenzo, Miragliotta, Vincenzo, Boccuto, Adele, Calandro, Pierpaolo, Andreini, Matteo, Tarditi, Alessia, Chiariello, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507746/
https://www.ncbi.nlm.nih.gov/pubmed/34638314
http://dx.doi.org/10.3390/cancers13194830

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8507746/
https://www.ncbi.nlm.nih.gov/pubmed/34638314
http://dx.doi.org/10.3390/cancers13194830

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