Cargando…

Metastatic Prostate Cancer Cells Secrete Methylglyoxal-Derived MG-H1 to Reprogram Human Osteoblasts into a Dedifferentiated, Malignant-like Phenotype: A Possible Novel Player in Prostate Cancer Bone Metastases

Bone metastases from prostate cancer (PCa) result from a complex cross-talk between PCa cells and osteoblasts (OB). Thus, targeting this interplay has become an attractive strategy to interfere with PCa bone dissemination. The agents currently used in clinical trials have proved ineffective, boostin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Antognelli, Cinzia, Marinucci, Lorella, Frosini, Roberta, Macchioni, Lara, Talesa, Vincenzo Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508123/ https://www.ncbi.nlm.nih.gov/pubmed/34638532 http://dx.doi.org/10.3390/ijms221910191

Ejemplares similares

Methylglyoxal Acts as a Tumor-Promoting Factor in Anaplastic Thyroid Cancer
por: Antognelli, Cinzia, et al.
Publicado: (2019)

Glyoxalase-1-Dependent Methylglyoxal Depletion Sustains PD-L1 Expression in Metastatic Prostate Cancer Cells: A Novel Mechanism in Cancer Immunosurveillance Escape and a Potential Novel Target to Overcome PD-L1 Blockade Resistance
por: Antognelli, Cinzia, et al.
Publicado: (2021)

Methylglyoxal-Dependent Glycative Stress Is Prevented by the Natural Antioxidant Oleuropein in Human Dental Pulp Stem Cells through Nrf2/Glo1 Pathway
por: Delle Monache, Simona, et al.
Publicado: (2021)

Glyoxalase 1−419C>A Variant Is Associated with Oxidative Stress: Implications in Prostate Cancer Progression
por: Antognelli, Cinzia, et al.
Publicado: (2013)

Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control
por: Antognelli, Cinzia, et al.
Publicado: (2018)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein S1 Induces Methylglyoxal-Derived Hydroimidazolone/Receptor for Advanced Glycation End Products (MG-H1/RAGE) Activation to Promote Inflammation in Human Bronchial BEAS-2B Cells
por: Manfredelli, Dominga, et al.
Publicado: (2023)

The Osteoblastic and Osteoclastic Interactions in Spinal Metastases Secondary to Prostate Cancer
por: Dushyanthen, Sathana, et al.
Publicado: (2013)

Tumor- and Osteoblast-Derived Periostin in Prostate Cancer bone Metastases
por: Sun, Chuan-Yu, et al.
Publicado: (2022)

Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme
por: Antognelli, Cinzia, et al.
Publicado: (2019)

Corrigendum to “Oleuropein-Induced Apoptosis Is Mediated by Mitochondrial Glyoxalase 2 in NSCLC A549 Cells: A Mechanistic Inside and a Possible Novel Nonenzymatic Role for an Ancient Enzyme”
por: Antognelli, Cinzia, et al.
Publicado: (2020)

Glyoxalases in Urological Malignancies
por: Antognelli, Cinzia, et al.
Publicado: (2018)

The dedifferentiation of metastatic prostate carcinoma.
por: Brawn, P. N., et al.
Publicado: (1989)

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte
por: Mezzasoma, Letizia, et al.
Publicado: (2017)

The Glyoxalase System Is a Novel Cargo of Amniotic Fluid Stem-Cell-Derived Extracellular Vesicles
por: Romani, Rita, et al.
Publicado: (2022)

Metabolic reprogramming in prostate cancer
por: Ahmad, Fahim, et al.
Publicado: (2021)

Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells
por: Li, Qinlong, et al.
Publicado: (2016)

Engineering osteoblastic metastases to delineate the adaptive response of androgen-deprived prostate cancer in the bone metastatic microenvironment
por: Bock, Nathalie, et al.
Publicado: (2019)

Natriuretic Peptides Regulate Prostate Cells Inflammatory Behavior: Potential Novel Anticancer Agents for Prostate Cancer
por: Mezzasoma, Letizia, et al.
Publicado: (2021)

Prostate cancer as a dedifferentiated organ: androgen receptor, cancer stem cells, and cancer stemness
por: Liu, Xiaozhuo, et al.
Publicado: (2022)

Mechanisms of Osteoblastic Bone Metastasis in Prostate Cancer: Role of Prostatic Acid Phosphatase
por: Quiroz-Munoz, Mariana, et al.
Publicado: (2019)

Exosomal prostate-specific G-protein-coupled receptor induces osteoblast activity to promote the osteoblastic metastasis of prostate cancer
por: Li, Yao, et al.
Publicado: (2020)

To bind or not to bind: Cistromic reprogramming in prostate cancer
por: Shen, Michelle, et al.
Publicado: (2022)

Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer
por: Lasorsa, Francesco, et al.
Publicado: (2023)

Alternating Differentiation and Dedifferentiation between Mature Osteoblasts and Osteocytes
por: Sawa, Naruhiko, et al.
Publicado: (2019)

Detection of CTC Clusters and a Dedifferentiated RNA‐Expression Survival Signature in Prostate Cancer
por: Kozminsky, Molly, et al.
Publicado: (2018)

Hypercalcemia due to parathyroid hormone-related peptide secreted by neuroendocrine dedifferentiated prostate cancer
por: Ando, Takashi, et al.
Publicado: (2018)

Exploring the Mechanisms of Differentiation, Dedifferentiation, Reprogramming and Transdifferentiation
por: Xu, Li, et al.
Publicado: (2014)

From Prostate to Bone: Key Players in Prostate Cancer Bone Metastasis
por: Thobe, Megan N., et al.
Publicado: (2011)

Observations on Prostatic Cancer with Metastases in Bone
por: Charteris, Alexander A.
Publicado: (1927)

Cavitary Lung Metastases in Prostate Cancer
por: Delbare, Felix, et al.
Publicado: (2022)

Dicarbonyl Stress and S-Glutathionylation in Cerebrovascular Diseases: A Focus on Cerebral Cavernous Malformations
por: Antognelli, Cinzia, et al.
Publicado: (2020)

The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review
por: Zhang, Xu, et al.
Publicado: (2023)

Endothelial Cells as Precursors for Osteoblasts in the Metastatic Prostate Cancer Bone
por: Paiva, Ana E., et al.
Publicado: (2017)

ODP134 Resistant Hypocalcemia in prostate cancer with osteoblastic metastasis
por: Hariharan, Vikaash, et al.
Publicado: (2022)

Metabolic Reprogramming by Malat1 Depletion in Prostate Cancer
por: Nanni, Simona, et al.
Publicado: (2020)

Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
por: Xu, Huan, et al.
Publicado: (2021)

Adipocytes reprogram prostate cancer stem cell machinery
por: Fontana, Fabrizio, et al.
Publicado: (2023)

Transient reprogramming of postnatal cardiomyocytes to a dedifferentiated state
por: Kisby, Thomas, et al.
Publicado: (2021)

Dedifferentiation and in vivo reprogramming of committed cells in wound repair
por: Guo, Yanjie, et al.
Publicado: (2022)

Expression and biological-clinical significance of hTR, hTERT and CKS2 in washing fluids of patients with bladder cancer
por: Mezzasoma, Letizia, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_d9c5gkbgog4a0lkpm89jtvvm2e