Cargando…

Microbe-Mediated Activation of Toll-like Receptor 2 Drives PDL1 Expression in HNSCC

SIMPLE SUMMARY: Tumors use immunosuppressive signals to evade detection by the immune system. While recurrent and metastatic head and neck squamous cell carcinoma has historically carried a poor prognosis, therapies targeting the immunosuppressive PD1:PDL1 axis have improved survival in certain pati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mann, Jacqueline E, Ludwig, Megan L, Kulkarni, Aditi, Scheftz, Erin B, Murray, Isabel R, Zhai, Jingyi, Gensterblum-Miller, Elizabeth, Jiang, Hui, Brenner, J Chad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508280/ https://www.ncbi.nlm.nih.gov/pubmed/34638266 http://dx.doi.org/10.3390/cancers13194782

Ejemplares similares

Protecting Tumors by Preventing Human Papilloma Virus Antigen Presentation: Insights from Emerging Bioinformatics Algorithms
por: Gensterblum-Miller, Elizabeth, et al.
Publicado: (2019)

Synthesis of Novel Peptide Dendrimers PDL-GB2 and PDL-G2
por: Yunzhu, Lin, et al.
Publicado: (2015)

Surveilling the Potential for Precision Medicine-driven PD-1/PD-L1-targeted Therapy in HNSCC
por: Mann, JE, et al.
Publicado: (2017)

Pharmacological tumor PDL1 depletion with chlorambucil treats ovarian cancer and melanoma: improves antitumor immunity and renders anti-PDL1-resistant tumors anti-PDL1-sensitive through NK cell effects
por: Bai, Haiyan, et al.
Publicado: (2023)

Toll-Like Receptors Recognize Intestinal Microbes in Liver Cirrhosis
por: Fan, Yujing, et al.
Publicado: (2021)

Identification of PDL1-Related Biomarkers to Select Lung Adenocarcinoma Patients for PD1/PDL1 Inhibitors
por: Wu, Yanping, et al.
Publicado: (2020)

Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients
por: Haase, Katharina, et al.
Publicado: (2021)

Identification of candidate genes and prognostic value analysis in patients with PDL1-positive and PDL1-negative lung adenocarcinoma
por: Qi, Xiaoguang, et al.
Publicado: (2020)

Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene
por: Heft Neal, Molly E., et al.
Publicado: (2021)

Identification of key genes for HNSCC from public databases using bioinformatics analysis
por: Ye, Yuchu, et al.
Publicado: (2021)

NR2F6 as a Prognostic Biomarker in HNSCC
por: Klapper, Luise, et al.
Publicado: (2020)

Transmission efficiency drives host–microbe associations
por: Leftwich, Philip T., et al.
Publicado: (2020)

Retroviral Replicating Vector Delivery of miR-PDL1 Inhibits Immune Checkpoint PDL1 and Enhances Immune Responses In Vitro
por: Lin, Amy H., et al.
Publicado: (2017)

lncRNA in HNSCC: challenges and potential
por: Guglas, Kacper, et al.
Publicado: (2017)

HNSCC: Tumour Antigens and Their Targeting by Immunotherapy
por: von Witzleben, Adrian, et al.
Publicado: (2020)

NF-Y Subunits Overexpression in HNSCC
por: Bezzecchi, Eugenia, et al.
Publicado: (2021)

The Impact of YRNAs on HNSCC and HPV Infection
por: Guglas, Kacper, et al.
Publicado: (2023)

Prognostic value of PDL1 expression in pancreatic cancer
por: Birnbaum, David J., et al.
Publicado: (2016)

PDL1 Expression on Plasma and Dendritic Cells in Myeloma Bone Marrow Suggests Benefit of Targeted anti PD1-PDL1 Therapy
por: Sponaas, Anne-Marit, et al.
Publicado: (2015)

Anlotinib Benefits the αPDL1 Immunotherapy by Activating ROS/JNK/AP-1 Pathway to Upregulate PDL1 Expression in Colorectal Cancer
por: Luo, Bixian, et al.
Publicado: (2022)

TRIM24 Expression as an Independent Biomarker for Prognosis and Tumor Recurrence in HNSCC
por: Klapper, Luise, et al.
Publicado: (2022)

In Vivo T Cell Activation Induces the Formation of CD209(+) PDL-2(+) Dendritic Cells
por: Davidson, Matthew G., et al.
Publicado: (2013)

Microbes Drive Evolution of Animals and Plants: the Hologenome Concept
por: Rosenberg, Eugene, et al.
Publicado: (2016)

CD73 is associated with poor prognosis in HNSCC
por: Ren, Zhen-Hu, et al.
Publicado: (2016)

Impact and Relevance of the Unfolded Protein Response in HNSCC
por: Pluquet, Olivier, et al.
Publicado: (2019)

Analyzing expression and phosphorylation of the EGF receptor in HNSCC
por: Kriegs, Malte, et al.
Publicado: (2019)

Review of biomarkers for response to immunotherapy in HNSCC microenvironment
por: Chen, Shaoshi, et al.
Publicado: (2023)

Prognostic and predictive value of PDL1 expression in breast cancer
por: Sabatier, Renaud, et al.
Publicado: (2014)

Stimulation of MMP-1 and CCL2 by NAMPT in PDL Cells
por: Nokhbehsaim, Marjan, et al.
Publicado: (2013)

Anion binding properties of a hollow PdL-cage
por: Timmer, Brian J. J., et al.
Publicado: (2021)

CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC
por: Paulsen, Finn-Ole, et al.
Publicado: (2020)

ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines
por: Ayoub, C, et al.
Publicado: (2010)

GDF15 Supports the Inflammatory Response of PdL Fibroblasts Stimulated by P. gingivalis LPS and Concurrent Compression
por: Stemmler, Albert, et al.
Publicado: (2021)

TRIM21 Expression as a Prognostic Biomarker for Progression-Free Survival in HNSCC
por: von Bernuth, Amelie, et al.
Publicado: (2023)

Toll-like receptor 4 and lipopolysaccharide from commensal microbes regulate Tembusu virus infection
por: Wu, Zhen, et al.
Publicado: (2022)

Differentially Expressed Genes, miRNAs and Network Models: A Strategy to Shed Light on Molecular Interactions Driving HNSCC Tumorigenesis
por: Arfin, Saniya, et al.
Publicado: (2023)

PDL1 Regulation by p53 via miR-34
por: Cortez, Maria Angelica, et al.
Publicado: (2015)

PDL regeneration via cell homing in delayed replantation of avulsed teeth
por: Zhu, Wenting, et al.
Publicado: (2015)

Regulation of Autophagic Signaling by Mechanical Loading and Inflammation in Human PDL Fibroblasts
por: Blawat, Kim, et al.
Publicado: (2020)

PDL1 expression on monocytes is associated with plasma cytokines in Tuberculosis and HIV
por: Tamene, Wegene, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_k9nvfiaov3mc09g395kuhfosca