MiR-125b-5p Is Involved in Sorafenib Resistance through Ataxin-1-Mediated Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

SIMPLE SUMMARY: The mechanism of resistance to multikinase inhibitors in hepatocellular carcinoma (HCC) remains unclear. We analyzed miRNA expression profiles in sorafenib-resistant HCC cell lines (PLC/PRF5-R1/R2) and parental cell lines (PLC/PRF5) to identify the responsible miRNAs and target genes...

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Detalles Bibliográficos
Autores principales: Hirao, Akihiro, Sato, Yasushi, Tanaka, Hironori, Nishida, Kensei, Tomonari, Tetsu, Hirata, Misato, Bando, Masahiro, Kida, Yoshifumi, Tanaka, Takahiro, Kawaguchi, Tomoyuki, Wada, Hironori, Taniguchi, Tatsuya, Okamoto, Koichi, Miyamoto, Hiroshi, Muguruma, Naoki, Tanahashi, Toshihito, Takayama, Tetsuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508441/
https://www.ncbi.nlm.nih.gov/pubmed/34638401
http://dx.doi.org/10.3390/cancers13194917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508441/
https://www.ncbi.nlm.nih.gov/pubmed/34638401
http://dx.doi.org/10.3390/cancers13194917

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