Profiling Cisplatin Resistance in Head and Neck Cancer: A Critical Role of the VRAC Ion Channel for Chemoresistance

SIMPLE SUMMARY: Treatment success of head and neck cancers (HNSCC) is often hindered by chemoresistance. In this study, next-generation sequencing transcriptomics and CRISPR/Cas9 knockout strategies were used to identify cisplatin resistance mechanisms and potential (personalized) biomarkers. Moreov...

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Detalles Bibliográficos
Autores principales: Siemer, Svenja, Fauth, Torsten, Scholz, Paul, Al-Zamel, Yara, Khamis, Aya, Gül, Désirée, Freudelsperger, Laura, Wollenberg, Barbara, Becker, Sven, Stauber, Roland H., Hagemann, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508519/
https://www.ncbi.nlm.nih.gov/pubmed/34638315
http://dx.doi.org/10.3390/cancers13194831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8508519/
https://www.ncbi.nlm.nih.gov/pubmed/34638315
http://dx.doi.org/10.3390/cancers13194831

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